Aftin4

Datasheet MSDS
Catalog Number
SGAM25629
Product Name
Aftin4
CAS Number
866893-90-5
Synonyms
Aftin 4 , Aftin-4 , Aftin-4 Aftin 4
Molecular Formula
C20H28N6O
Molecular Weight
368.48
Purity
99.03%
Solubility
DMSO: 25 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 can thus be used to induce a rapid, acute Alzheimer's disease-like toxicity in the rodent brain.
Target
γ secretase(Aβ42)
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