Boc-Val-Cit-PAB-PNP

Datasheet MSDS
Catalog Number
RP0040
Product Name
Boc-Val-Cit-PAB-PNP
Structure
Boc-Val-Cit-PAB-PNP
CAS Number
870487-10-8
IUPAC Name
[4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoyl]amino]pentanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate
Synonyms
EX-A4143
Molecular Formula
C30H40N6O10
Molecular Weight
644.7
Purity
95%
Storage
-20°C
Description
Boc-Val-Cit-PAB-PNP is a linker for Antibody-Drug-Conjugation (ADC). The Val-Cit will specifically be cleaved by catepsin B. As this enzyme is only present in the lysosome the ADC payload will be release only in the cell.
SMILES
CC(C)C(C(=O)NC(CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)COC(=O)OC2=CC=C(C=C2)[N+](=O)[O-])NC(=O)OC(C)(C)C
InChI
InChI=1S/C30H40N6O10/c1-18(2)24(35-28(40)46-30(3,4)5)26(38)34-23(7-6-16-32-27(31)39)25(37)33-20-10-8-19(9-11-20)17-44-29(41)45-22-14-12-21(13-15-22)36(42)43/h8-15,18,23-24H,6-7,16-17H2,1-5H3,(H,33,37)(H,34,38)(H,35,40)(H3,31,32,39)/t23-,24-/m0/s1
InChI Key
SKWLDDHVHXQPOG-ZEQRLZLVSA-N
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