AIM100

Datasheet MSDS
Catalog Number
SACK28586
Product Name
AIM100
CAS Number
873305-35-2
Synonyms
AIM 100 , AIM-100 , AIM-100 AIM 100
Molecular Formula
C23H21N3O2
Molecular Weight
371.43
Purity
98.75%
Solubility
DMSO: 30 mg/mL Ethanol: 30 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
AIM-100 is a Ack1 inhibitor (IC50: 24 nM).
Description
AIM-100 not only inhibited Ack1 activation but also suppressed AKT tyrosine phosphorylation, leading to cell cycle arrest in the G1 phase [1]. It also was able to suppress AR Tyr(267) phosphorylation and its recruitment to the ATM enhancer. Notably, AIM-100 suppressed Ack1 mediated ATM expression and mitigated the growth of radioresistant CRPC tumors [2]. AIM-100, not only inhibited Ack1 activation but also able to suppress pTyr267-AR phosphorylation, binding of AR to PSA, NKX3.1, and TMPRSS2 promoters, and inhibit AR transcription activity [3].
Target
Ack1
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