Crizotinib

Datasheet MSDS
Catalog Number
SALK10003
Product Name
Crizotinib
CAS Number
877399-52-5
IUPAC Name
3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine
Synonyms
PF-02341066
Molecular Formula
C21H22Cl2FN5O
Molecular Weight
450.34
Appearance
White Solid
Purity
99.87%
Density
1.47±0.1 g/cm3 (Predicted)
Solubility
2eq.HCl: 45 mg/mL (100 mM) DMSO: 4.5 mg/mL (10 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Melting Point
192 °C
Boiling Point
599.2±50.0 °C (Predicted)
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
Crizotinib is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.
SMILES
C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
InChI
InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1
InChI Key
KTEIFNKAUNYNJU-GFCCVEGCSA-N
Target
ALK, c-Met
Inquiry

new products