GS-143

Datasheet MSDS
Catalog Number
SIKB26292
Product Name
GS-143
CAS Number
916232-21-8
Synonyms
GS143 , GS 143
Molecular Formula
C28H19FN2O4
Molecular Weight
466.46
Purity
99.72%
Solubility
DMSO: 40 mg/mL (85.75 mM, Need ultrasonic ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
GS143 is a selec­tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup­presses NF-κB acti­va­tion and tran­scrip­tion of tar­get genes and does not inhibit proteasome activity. GS143 has anti-asthma effect
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