PF-562271 besylate

Datasheet MSDS
Catalog Number
SFAK10359
Product Name
PF-562271 besylate
CAS Number
939791-38-5
Synonyms
PF-00562271 Besylate, PF-00562271 Besylate
Molecular Formula
C21H20F3N7O3S·C6H6O3S
Molecular Weight
665.66
Purity
99.50%
Solubility
DMSO: 12 mg/mL (18 mM) Ethanol: <1 mg/mL Water: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
PF-00562271 Besylate (PF-562271) is the benzene sulfonate of PF-562271, a potent, ATP competitive, reversible FAK inhibitor with an IC50 of 1.5 nM, acting on Pyk2 is about 10 times less effective than acting on FAK, and more than 100 times more selective than acting on other protein kinases (except for some CDKs). Phase 1。
Target
CDK1/CyclinB, CDK2/CyclinE, CDK3/CyclinE, FAK, PYK2
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