PHA767491 HCl

Datasheet MSDS
Catalog Number
SCDK11878
Product Name
PHA767491 HCl
CAS Number
942425-68-5
Synonyms
CAY-10572 hydrochloride , PHA-767491 hydrochloride , PHA-767491 , CAY10572 , PHA-767491 hydrochloride , PHA-767491 , CAY10572 , CAY-10572 hydrochloride
Molecular Formula
C12H12ClN3O
Molecular Weight
249.69
Purity
99.92%
Solubility
DMSO: 25 mg/mL (100 mM) water: 25 mg/mL (100 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
PHA-767491 is an effective ATP-competitive dual Cdc7/CDK9 inhibitor (IC50: 10/34 nM). It has ~20-fold selectivity against GSK3-β and CDK1/2, 50-fold selectivity against CDK5 and MK2, 100-fold selectivity against CHK2 and PLK1.
Target
Cdc7, Cdk1, Cdk2, Cdk9, GSK-3β
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