A-674563 HCl (552325-73-2(free base))

Datasheet MSDS
Catalog Number
SAKT26862
Product Name
A-674563 HCl (552325-73-2(free base))
Molecular Formula
C22H23ClN4O
Molecular Weight
394.9
Purity
99.69%
Solubility
DMSO: >30 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 (IC50: 16/46 nM) but is 10- to >1, 800-fold selective for Akt1 versus additional kinases in the CMGC, CAMK, and TK families [1].
Target
Akt1, CDK2, PKA
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