A 83-01 sodium salt

Datasheet MSDS
Catalog Number
SALK28631
Product Name
A 83-01 sodium salt
Molecular Formula
C25H19N5NaS
Molecular Weight
444.51
Solubility
DMSO: 100 mg/mL (224.97 mM), Need ultrasonic H2O: < 0.1 mg/mL (insoluble) ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
A 83-01 sodium salt is a potent inhibitor of ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50s: 12, 45 and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7).
Description
A 83-01 sodium salt reduces the level of ALK-5-induced transcription with an IC50 of 12 nM in Mv1Lu cells, also blocks the ALK4-TD and ALK7-TD induced transcription with IC50s of 45 nM and 7.5 nM in R4-2 cells, and weakly suppresses that induced by constitutively active ALK-6, ALK-2, ALK-3, and ALK-1. A 83-01 (0.03-10 µM) potently prevents the growth-inhibitory effects of TGF-β, and completely inhibits the effect at 3 µM. A 83-01 (1-10 µM) inhibits TGF-β-induced Smad activation in HaCaT cells [1]. A 83-01 (1 µM) decreases cell motility, adhesion and invasion increased by TGF-β1 in HM-1 cells, but does not change cell proliferation [2].
Target
ALK5, cell-based, ALK4 cell-based, ALK7 cell-based
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