AZ12601011

Datasheet MSDS
Catalog Number
SALK10043
Product Name
AZ12601011
Molecular Formula
C19H15N5
Molecular Weight
313.36
Solubility
DMSO: 5 mg/mL (15.96 mM), Need ultrasonic ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor with an IC50 of 18 nM and a Kd of 2.9 nM. AZ12601011 inhibits phosphorylation of SMAD2 via selectively inhibiting ALK4, TGFBR1, and ALK7. AZ12601011 inhibits mammary tumor growth .
Target
TGFBR1, ALK4
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