AZ12601011

Datasheet MSDS
Catalog Number
SALK28628
Product Name
AZ12601011
Molecular Formula
C19H15N5
Molecular Weight
313.36
Solubility
DMSO: 5 mg/mL (15.96 mM), Need ultrasonic ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor (IC50: 18 nM; Kd: 2.9 nM) with inhibitory to mammary tumor growth. AZ12601011 inhibits phosphorylation of SMAD2 via selectively inhibiting TGFBR1, ALK4, and ALK7.
Description
AZ12601011 (0.01-10 μM; for 20 minutes) completely inhibits the Phosphorylation of SMAD2. AZ12601011 (0.01 µM-10 µM) inhibits the activity of ALK4, ALK7, and TGFBR1. AZ12601011 inhibits 4T1 cell growth in vitro (IC50: 0.4 µM).
Target
TGFBR1, ALK4
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