CEP-28122 mesylate salt

Catalog Number
SALK28624
Product Name
CEP-28122 mesylate salt
Synonyms
CEP-28122 mesylate salt (1022958-60-6 free base)
Molecular Formula
C29H39ClN6O6S
Molecular Weight
635.17
Purity
99.19%
Solubility
DMSO: 6.4 mg/mL (10.08 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
CEP-28122 mesylate salt is a highly selective orally active ALK inhibitor (IC50: 1.9 nM in an enzyme-based TRF assay).
Description
CEP-28122 is a potent inhibitor of recombinant ALK activity and cellular ALK tyrosine phosphorylation. CEP-28122 also inhibits Flt4 (IC50: 46 nM). CEP-28122 induces concentration-dependent growth inhibition/cytotoxicity of ALK-positive anaplastic large-cell lymphoma (ALCL), neuroblastoma cells, and non-small cell lung cancer (NSCLC).
Target
Others
Inquiry

new products